Oxymetholone (Anadrol) 50mg by Dragon Pharma — Complete Guide
Substance: Oxymetholone (Anadrol)
Package: 100 tabs × 50mg
Anabolic/Androgenic: 320:45
Detection time: 8-9 weeks
What is Oxymetholone (Anadrol)?
Oxymetholone (brand name Anadrol-50) is one of the most powerful oral anabolic steroids ever developed. First synthesized in 1960 by Syntex and later marketed by Unimed, Anadrol was originally designed to treat anemia and osteoporosis. It remains the gold standard for rapid, extreme mass and strength gains.
Anadrol is known for producing dramatic weight gains of 10-20+ lbs within 2-4 weeks — faster than any other oral steroid. It is considered a “nuclear option” for hardgainers and experienced users seeking maximum size and strength. However, these gains come with significant side effects, including severe water retention, hepatotoxicity, and androgenic effects.
Anadrol is one of the most potent and toxic oral steroids available. It is strictly for advanced users. DO NOT use it for first cycles. The side effects are severe and can include liver damage, dangerously high blood pressure, severe water retention, and significant estrogenic sides. Beginner oral users should start with Dianabol, Turinabol, or Anavar.
⚙️ How Does Anadrol Work?
Oxymetholone is a 17-alpha-alkylated DHT-derived compound with unique mechanisms:
- ⬆ Extreme protein synthesis — Dramatically increases nitrogen retention
- ⬆ Red blood cell production — Significant erythropoiesis (30-50% increase in RBCs)
- ⬆ IGF-1 production — Elevates insulin-like growth factor levels
- ⬆ Appetite stimulation — Increases hunger, allowing massive caloric intake
- ⬆ Direct estrogen receptor activation — Unique mechanism: no aromatization, but strong estrogen agonist activity → gynecomastia and water retention without elevated serum E2
- No progestin activity — No prolactin side effects
Anadrol 50mg — Dosage Protocols
| User Level | Daily Dose (50mg tabs) | Daily Dose (mg) | Cycle Length | Expected Weight Gain |
|---|---|---|---|---|
| Beginner (with AAS experience) | 0.5-1 tab (split) | 25-50mg | 3-4 weeks | 8-12 lbs (4-6 lbs keepable) |
| Intermediate | 1 tab | 50mg | 4-5 weeks | 12-18 lbs (6-10 lbs keepable) |
| Advanced | 1-2 tabs (split) | 50-100mg | 4-6 weeks | 15-25 lbs (8-12 lbs keepable) |
Critical: Never exceed 6 weeks on Anadrol. The hepatotoxicity is cumulative and severe. 4 weeks is optimal for safety. Split doses (morning/evening) due to 8-9 hour half-life.
Expected Results — What Users Report
- Week 1-2: Rapid strength increase (30-50 lbs on bench press), full muscle bellies, significant water weight gain
- Week 3-4: Maximum fullness, extreme pumps, noticeable mass gain, appetite increase
- Week 5-6: Peak size and strength, but side effects accumulate (lethargy, high BP, liver stress)
- Post-cycle: 30-50% of weight is water; proper PCT and nutrition determine muscle retention
Anadrol vs Other Orals — Comparison
| Compound | Gain Speed | Gain Quality | Water Retention | Hepatotoxicity | Androgenicity | Strength Gain |
|---|---|---|---|---|---|---|
| Anadrol | Fastest | Low (mostly water) | Very High | Very High | High | Extreme |
| Dianabol | Fast | Moderate | High | High | Moderate | High |
| Superdrol | Fast | High (dry) | None | Extreme | Low | Very High |
| Turinabol | Slow | High (dry) | None | Moderate | Low | Moderate |
⚠️ Severe Side Effects — Anadrol is NOT for everyone
One of the most liver-toxic orals. ALT/AST elevations 5-15x normal. Use limited to 4-6 weeks. Liver support MANDATORY.
Facial bloating, moon face, puffy skin. Direct estrogen receptor activation causes water retention without high E2 levels.
Direct estrogen agonist activity can cause gyno even with normal E2 levels. Nolvadex is often required.
Significant water retention + increased RBC production → BP often exceeds 140/90.
HDL crashes to single digits within weeks. LDL rises significantly. Full recovery takes 4-8 weeks.
Extreme fatigue common by week 4-5. Some users report appetite loss despite Anadrol’s reputation.
️ Mandatory Liver Support Protocol (NON-NEGOTIABLE)
| Supplement | Daily Dose | Timing | Purpose |
|---|---|---|---|
| NAC (N-Acetylcysteine) | 1800-2400mg | Split AM/PM | Glutathione precursor, potent liver antioxidant |
| TUDCA | 750-1000mg | Take 2-3 hours apart from Anadrol | Bile acid, direct hepatoprotection, bile flow support |
| Milk Thistle (Silymarin) | 1000-1500mg | With food | Antioxidant, liver cell membrane stabilization |
Anadrol Stacking Protocols
Testosterone Enanthate/Cypionate 500-750mg/week. Never run Anadrol without testosterone — severe suppression causes low T symptoms within days.
Test E 750mg + Deca 600mg + Anadrol 50-100mg (weeks 1-4). Extreme mass and strength.
Combining Anadrol with Dianabol, Superdrol, Winstrol, or other 17-alpha-alkylated orals dramatically increases hepatotoxicity. Liver failure is a real risk. Use Anadrol alone as a kickstart with injectable testosterone.
Blood Pressure Management on Anadrol
- Monitor BP daily — Expect elevated readings; above 140/90 requires intervention
- Limit sodium intake — Reduce dietary salt to minimize water retention
- Increase potassium — Bananas, spinach, coconut water help balance electrolytes
- Cardiovascular exercise — 20-30 minutes daily to maintain heart health
Post Cycle Therapy (PCT) — Aggressive Protocol Required
- Week 1-2: HCG 500-1000iu EOD (if available)
- Week 1-4: Clomid 50/50/25/25
- Week 1-4: Nolvadex 40/40/20/20
- Week 1-6: Continue liver support for full recovery
Start PCT 24-48 hours after last Anadrol dose. Wait 2 weeks after last testosterone injection if using long esters.
Who Should NEVER Take Anadrol?
- Anyone without prior AAS experience — Anadrol is an advanced compound only
- Individuals with pre-existing liver conditions (hepatitis, fatty liver, elevated ALT/AST)
- Those with cardiovascular disease, high BP, or high cholesterol
- Individuals prone to gyno (estrogen sensitivity)
- Anyone unwilling to commit to mandatory liver support and blood work


