Tadalafil is a PDE5 inhibitor, presently produced in pill form for treating erectile dysfunction and often sold under the brand name Cialis for the treatment of pulmonary arterial hypertension. It has the longer half-life that other similar products and it is the basis for current investigation of Tadalafil’s daily therapeutic use in relieving pulmonary arterial hypertension. For sexual health it works naturally because it still requires sexual stimulation for the penis to develop an erection. Its main role is to increase blood flow to the penis.


The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. However, because sexual stimulation is required to initiate the local penile release of nitric oxide, Tadalafil’s inhibition of PDE5 will have no effect without direct sexual stimulation of the penis. The recommended Tadalafil Citrate starting dose for most men is 10 mg, taken as needed before sexual activity (but not more than once daily).


Since PDE5 inhibitors such as Tadalafil may cause transiently low blood pressure (hypotension), organic nitrates should not be taken for at least 48 hours after taking the last dose of Tadalafil. The use of organic nitrites (such as the sex drug amyl nitrite) within this period may increase the risk of life-threatening hypotension. The most common side effects when using Tadalafil are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects reflect the ability of PDE5 inhibition to cause blood vessels to widen and usually go away after a few hours.


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