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Clomiphene citrate (Clomid)

Clomifene represents a selective estrogen receptor modulator (SERM) that increases production of gonadotropins by inhibiting negative feedback on the hypothalamus. Medically it is used in female infertility, in turn mainly as ovulation induction to reverse oligoovulation or anovulation such as in infertility in polycystic ovary syndrome, as well as being used for ovarian hyperstimulation, such as part of an in vitro fertilization procedure. Clomifene Citrate is marketed under various trade names including Clomid, Serophene, and Fertomid.


Clomifene appears to inhibit estrogen receptors in hypothalamus, thereby inhibiting negative feedback of estrogen on gonadotropin production. It may also result in direct stimulation of the hypothalamic–pituitary–adrenal axis.


Among athletes and bodybuilders it is commonly used as a recovery medication and taken toward the end of a steroid cycle. First of all Clomifene is utilized to overcome gynocomastia and raise the body’s natural testosterone levels. Clomifene Citrate works by minimizing or blocking the effects of estrogen in the body. It is chemically a synthetic estrogen with antagonist properties, and is very similar in structure and action to Tamoxifen. In certain tissues Clomifene Citrate blocks the ability of estrogen to bind with its corresponding receptor. By restoring the natural Testosterone levels it helps the athlete’s body to preserve the gained size and strength of the muscles.


Clomiphene Citrate is an effective antagonist in the hypothalamus and in breast tissue. It is an effective agonist in bone tissue, and for improving blood cholesterol. It also has the property to reduce the adverse effect of damage of muscle tissues as a result of exercises. This compound is mainly used by men and is not so popular among female athletes. Clomifene citrate can be taken with HCG – Human Chorionic Gonadotropin in order to achieve an immediate result in Testosterone boosting and can also be used as a maintenance anti-estrogen drug during a steroid cycle.


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